Preclinical Therapeutics

万博体育 九州 365365体育会不会倒闭365bet体育在线手机版The preclinical therapeutics core facility generates tumor-bearing mice and conducts preclinical oncology trials. The core utilizes xenograft tumor models in immune-deficient mice, as well as a large variety of genetically engineered models of tumors that are initiated by known cancer genes. Since these tumor models have well defined oncogenic alterations, they are suitable for testing the therapeutic efficacy of investigational drugs that target oncoproteins directly or indirectly through synthetic lethal interactions. These therapeutics are tested either individually or in rational combinations. The core facility staff will help handle compound formulation and delivery, tumor and animal monitoring, tissue collection, as well as pharmacokinetic (PK) and pharmacodynamic (PD) analysis. The facility is housed with the Pearl Trilogy?in vivo imaging system from Li-Cor for noninvasive imaging of small animals.? With centralized animal resources and competent personnel specializing in preclinical studies, this core ensures appropriate experimental design, reproducibility of experimental data, maximum resource utilization, and compliance with local and national regulatory guidelines for experimental animals.

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